ATI-502 Topical JAK Inhibitor for Alopecia Areata Did Not Show Benefit

The JAK inhibitors are a group of medications that have been shown to benefit alopecaia areata when taking in the oral form. Tofacitinib Ruxolitinib and Baricitinib are pills that have shown benefit in alopecia areata and are frequently used off label in more advanced forms of the disease.

There has been a massive surge in interest in studying whether topical JAK inhibitors could provide benefit. Companies such as Aclaris are studying various JAK inhibitors for alopecia areata. I was interested to note this week the final results that were published by Aclaris Therapeutrics regarding their Phase 2 clinical trial of ATI-502 (also known as AA-201) a ‘topical’ JAK inhibitor for alopecia areata. The study showed that the topical JAK inhibitor treatment did not prove more effective than the placebo.

The study was a double blinded placebo controlled trial which evaluated two concentrations of AT-502, namely 0.12 % and 0.46 %. Participants applied the treatment twice daily for 24 weeks.

READ ACLARIS NEWS RELEASE SHOWS NO BENEFITS FOR ATI-502

COMMENT

These studies of topical JAK inhibitors are very important (and so are the studies of course with the oral JAK inhibitors). While it would seem that topical JAK inhibitors should help if the oral forms help, that needs to be proven in well conducted trials. The formulation of the JAK inhibitor is clearly important as previous studies showed the some formulations - like ointments - are quite ineffective. A 2018 study by Liu, Craiglow and King did not find the 2 % ointment to be all that helpful.

TOPICAL TOFACITINIB OINTMENT NOT VERY HELPFUL FOR ALOPECIA AREATA

It will be interesting to see if other topical JAK inhibitors have positive results in ongoing studies.