Per a recent email update, the Age Reversal Network recently received a sizable charitable donation that will be used to fund studies at Betterhumans. The Betterhumans organization runs clinical studies of senolytics and other present means that might make a difference in the progression of aging. It is always good to see high net worth individuals stepping up to make a difference in this way. It is still the case, even now that a great deal of venture funding is arriving to build out a longevity industry, that many useful and important projects are run by non-profits and academics.

The Age Reversal Network is a venture led by some of the same principals as the Life Extension Foundation and RAADfest. The focus is on presently available technologies that might work now to slow or reverse aspects of aging, which to their eyes means senolytic compounds, particularly the dasatinib and quercetin combination, mTOR inhibitors, NAD+ enhancement by various means, and some stem cell therapies. Proposed activities include running trials to prove effectiveness, building out physician networks willing to prescribe off-label, and advocating for the broader use of these approaches. This is all conditional on raising sufficient funding, which so far has proven just as challenging as it is for everyone else on the non-profit side of the longevity community.

I recently met with an Age Reversal Network member and he asked me what was needed to accelerate critical research initiatives. After describing projects that lacked funding, this supporter responded with a $1 million donation. It's the largest single contribution we've ever received! I directed this donation to a charity called Betterhumans that we work with, and financially support ourselves. The focus of Betterhumans is to conduct proof-of-concept clinical studies and rapidly generate results. It is via this fast-tracked approach that regenerative effects of senolytics, NAD+ infusions and patches, and exosomes have been identified in humans.

Here is an update on donations received by our charity so far: we have so far raised $148,000 prior to this sizable donation. These funds are currently in an interest-bearing account. They will soon be used to launch the first study of about 30 people involving a sequence of interventions that aim to achieve meaningful rejuvenation across a broad-spectrum of age-associated pathologies. Evidence of systemic regeneration will include clinical measures (such as blood pressure and kidney function), aging biomarkers (such as methylation patterns and inflammatory indicators) and symptomatic changes (such as better sleep and improved physical endurance).

If this 30-person study was funded by a pharmaceutical company, it would cost many millions of dollars. The good news is that medical professionals and others are donating their time, equipment and office space to keep the costs down to a minimum. Our current budget estimate for this first clinical trial is only $250,000. It will be partially self-funded by study participants so that donations received to date by the Human Age Reversal Project charity will cover most of the study costs. We ideally need about $100,000 more to fully cover its costs. I therefore ask those who can afford it to make tax-deductible contributions to this critical research endeavor.